Turkeyfoot Preserve is located southwest of Greenville with convenient access and parking located just off OH-121 on Bishop Road. The preserve is the result of the Natural Resources Conservation Service Wetlands Reserve Program with additional funding through the Clean Ohio Conservation Fund. Darke County Parks acquired this preserve in 2001 with the intent to maintain the wetlands, re-establish prairie and provide for public access and passive recreation.

A gravel serpentine trail takes the visitor from the parking lot north along an old railroad bed, a donation by Vectren Energy Delivery of Ohio and Panhandle Pipeline Inc. The trail leads to the east edge of the preserve with access trails to the prairie and the wetlands. An observation deck at the top of a gentle hill provides a panoramic view of the Tawaskote Menitsa Prairie.