Knoxville Recreation Area is managed by the Bureau of Land Management and is best accessed by turning west off Berryessa Knoxville Road at Devil's Head Road, located +/- 17 miles north of the Putah Creek Bridge. Devil's Head Road is a public gravel road that leads to the hiking, mountain biking, and equestrian trails as well as to the staging area for off-road-vehicles (OHV).

Camping is available at Lower Hunting Creek, located at the intersection of Dunnigan Hill Road and Hunting Creek Road at Hunting Creek.  This developed campground has 5 sites with shade structures, vault toilet, trash cans, and 3 overflow campsites. There is no potable water at the site (bring your own drinking water). There are no fees and no reservations. Campsite availability is on a first-come, first-serve basis. Cedar Creek, Cement Creek, and Pocock Creek are primitive camps with no facilities. Firewood Gathering: Cutting or removing standing vegetation (live or dead), is strictly prohibited. Use only wood that is both dead and down for firewood.